NMN and NAD Reverse Aging of Blood Vessels in New Study

Using the NAD boosting molecule NMN, Dr. David Sinclair’s team reversed blood vessel and muscle aging in mice, while boosting their exercise endurance.  As Dr. Sinclair says

“We’ve discovered a way to reverse vascular aging by boosting the presence of naturally occurring molecules in the body that augment the physiological response to exercise” adding “The approach stimulates blood vessel growth and boosts stamina and endurance in mice and sets the stage for therapies in humans to address the spectrum of diseases that arise from vascular aging.”

The team says the achievement paves the way for similar therapies for humans and published the results of their study on March 22 in the journal Cell.

David A. Sinclair, Ph.D. is best known for his research on the NAD molecule and its role in increasing health in aging bodies. Dr. Sinclair is a professor in the Department of Genetics and a Co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard Medical School (HMS) as well as a Professor at the University of New South Wales, Sydney.

In a video accompanying the new study, published by Harvard News, Dr. David Sinclair describes the compound NMN boosts levels of NAD in the bodies of aging mice, and how that restores muscle function.

 

 

Vascular aging leads to a deterioration in many organs and tissues throughout the human body, as Dr. David Sinclair says:

“As we age, the tiniest blood vessels in our bodies wither and die, reducing the blood flow to organs and tissues. Vascular aging causes many diseases — cardiovascular, neurological, muscle wasting, frailty, and even aging. Here at Harvard Medical School, we’ve reversed the process in mice, setting the stage for radical new therapies to help people. The new study has unraveled the cascade of interactions between blood vessels and muscles. “

NMN Boosts NAD in aging endothelial cells. Source: Harvard Medical School (HMS)
NMN Boosts NAD in aging endothelial cells. Source: Harvard Medical School (HMS) (video).

Dr. David Sinclair also describes the how aging of the cells lining our blood vessels leads to a decline in our vascular systems and muscles, saying:

“Endothelial cells, which line the walls of blood vessels, are essential for the health and growth of the vessels. And as endothelial cells age, blood vessels begin to atrophy and die. Blood flow to many parts of the body diminishes, organs and tissues begin to function less well. Blood vessel demise hits muscles especially hard because muscles rely on a robust blood supply for their function. This process can be slowed down with regular exercise, but only up to a point. Over time, even exercise fails to stave off blood vessel demise and muscle loss. “


The decline in NAD causes aging blood vessels and loss of muscle tissue says Dr. David Sinclair. Credit: Lewis Lipsitz via HMS.

The new study suggests that this loss of blood flow is a key driver behind age-related muscle loss and frailty. Even if we exercise, our muscles shrink as we get older, as Dr. David Sinclair says

“The new findings have cracked the mystery behind this process. As our blood vessels age, they become deaf to the signals from exercise muscles. This actually leads to the muscles shrinking as we get older, and therefore we’re less able to exercise and grow new blood vessels. A vicious cycle indeed. “


NMN boosts NAD in aging blood vessels according to Dr. David Sinclair. Source: HMS (video).

The declining levels of NAD in our bodies cause this aging process. However,  using NMN to boost levels of NAD stimulates a sirtuin protein called SIRT1, as Dr. David Sinclair describes

“The two key players in the crosstalk between blood vessels and muscles are a molecule called NAD and a protein called SIRT1. NAD boosts SIRT 1, which in turn enables the conversation between muscles and blood vessels. But both NAD and SIRT1 decline as we age. They can no longer perform their role as the interface between muscles and blood vessels.”

Finally, the researcher describes how giving the compound NMN to mice boosted their levels of NAD, producing remarkable results, as Dr. David Sinclair says,

“In our new study, we gave mice NMN, a chemical compound commonly found in the body and previously shown to boost NAD levels, which in turn boosts SIRT1. These mice had better endothelial function, blood vessel growth and improved blood supply to their muscles. “


Mice treated with NAD booster NMN outperform untreated ones. Source: Dr.  Sinclair / HMS.

The most striking effect of was a significant boost in the mice’s ability to exercise. The aging mice treated with NMN gained between 56 and 80 percent greater exercise capacity, compared with untreated ones by being able to run much farther on a treadmill.  According to Dr. Sinclair, the mice treated with NMN had improved exercise capacity due to improvements in vascular function, saying

“And what was most striking? These animals’ capacity for exercise improved dramatically. In fact, the old mice treated with NMN had up to 80 percent greater exercise capacity, compared with the untreated old mice.”


Dr. David Sinclair suggests that NMN and NAD may reverse aging in blood vessels and restore the muscle tissue of Seniors one day. Credit: Dr. David Sinclair / Harvard Medical School.

Sinclair believes that the results achieved in mice can eventually be translated to humans, helping to counter age-related diseases with a vascular component, such as frailty, heart attact, stroke or even forms of dementia such as Alzheimer's disease. As Dr. David Sinclair says in his parting words,

“These results, I believe, can help millions of people who have lost their mobility, or simply can no longer exercise, either through frailty, disability or old age. This sets the stage for new medicines that will be able to restore blood flow in organs that have lost it, either through a heart attack, a stroke or even in patients with dementia“